p-Toluenesulfonic acid → HCID 18663628, compound

Participants

Reaction Steps

Preparation analogous to Example 2 from 10-bromomethyl-dibenz[b,f]oxepine and N-methyl-N-propylamine. Tosylate prepared with 1 equivalent of p-toluenesulfonic acid in ethyl acetate, crystallised from dichloromethane/tert-butyl methyl ether. Yield: 68%; melting point: 179°-180° C.; 1H-NMR (CD3OD, 200 MHz): 0.97 (t, 3H); 1.78 (m, 2H); 2.36 (s, 3H); 3.15 (mbr, 2H); 4.50 (mbr, 2H); 7.17-7.75 (m, ca. 13H); MS: 279 (M+, free base), 250, 207.

Provenance & Evidence