Hydrogen Bromide → HCID 22378381, compound

Participants

Reaction Steps

17.5 g (70.94 mmol) of (2-chloro-6-phenoxy-phenyl)-methanol are heated under reflux for 3 hours in 150 ml of 48% hydrobromic acid. The mixture is cooled, water is added and the mixture is extracted 3× with ethyl acetate. The organic phases are washed with brine, dried over sodium sulfate and concentrated. 21.21 g (>1 00%) of crude (2-chloro-6-phenoxy-phenyl)-bromomethane are obtained in the form of a yellow oil; TLC (silica gel; ethyl acetate/hexane=1:1; UV): Rf =0.70; 1H-NMR (CDCl3, 200 MHz): 4.78 (s, 2H); 6.70-7.41 (m, 8H).

Provenance & Evidence