Phenyl isocyanate → HCID 21184685, compound

HRID 1956618Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[C:9]1([N:15]=[C:16]=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:9]1([NH:15][C:16]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[SH:8])=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 7672Phenyl isocyanate

HCID 87132-Aminothiophenol

Product 1

HCID 21184685HCID 21184685, compoundYield 85%

Procedure

2- {[(Phenylamino)carbonyl]amino }thiophenol was prepared from 2-aminothiophenol (200 mg, 1.6 mmol) and phenyl isocyanate according to the procedure in General Method A. The product was purified by precipitation from toluene and filtering to afford the titled compound (330 mg, 85%). mp: 194.5° C.; 1H NMR (CD3 OD/CDCl3): d 7.48-7.26 (m, 4H), 7.25-7.10 (m, 3H), 7.04-6.79 (m, 2H); El-MS m/z 244 (M+H)+ ; Anal. (C13H12N2OS) C, H, N.

Workup

customThe product was purified by precipitation from toluene
filtrationfiltering

Sources & evidence

ORD record: ord-abdad82167984f37b13ca7f73bff5e82
Source dataset: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05780483

Reaction notes

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