2,4-Difluorobenzylamine → 3-(2,4-Difluoro-benzylamino)-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione

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Reaction Steps

This compound was prepared according to the procedure for Example 59. From 3-ethoxy-4-(1,1 -dimethyl-propylamino)-cyclobut-3-ene- 1,2-dione and 2,4-difluorobenzylamine in acetonitrile. The title compound was obtained, after recrystallization from diethyl ether, as a white solid (80%): mp 242°-244° C.; 1H NMR (DMSO-d6) δ0.82 (t, 3H), 1.30 (s, 6H), 1.68 (q, 2H), 4.76 (d, 2H), 7.09 (m, 1H), 7.27 (m, 1H), 7.50 (m, 2H), 7.80 (m, 1H) ppm; IR (KBr) 3250, 3150, 2970, 1790, 1652, 1580, 1538, 1510 cm-1 ; MS (m/z) 309 ([M+H]+).

Provenance & Evidence