Benzenemethanamine, 2,5-dichloro- → 3-tert-Butylamino-4-(2,5-dichloro-benzylamino)-cyclobut-3-ene-1,2-dione

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Reaction Steps

Employing the procedure of Example 2, Step 4, and a reaction period of 23 hours, 2,5-dichlorobenzylamine (0.88 g, 5 mmol) and 3-butoxy-4-tert-butylamino-cyclobut-3-ene-1,2-dione (1. 13 g, 5 mmol) in tetrahydrofuran (15 mL ) were converted to 1.52 g of a cream-colored solid. Recrystallization of this material from acetonitrile (twice) and from methanol provided 0.853 g of the tide compound as a white solid: mp 236° C. (softens 216° C.). MS (m/z) 326/328/330 (M+).

Provenance & Evidence