2,3-Dichlorobenzylamine → HCID 54225953, compound

Participants

Reaction Steps

Tetrahydrofuran (12 mL), 3-butoxy-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione (1,20 g, 5.0 mmol) and 2,3-dichlorobenzylamine (0.88 g, 5.0 mmol) were stirred together at room temperature for 64 hours. The residue remaining after removal of solvent was trituated thoroughly with diethyl ether and dried to give 1.55 g of a white solid. Recrystallization (four times) of the crude product from acetonitrile provided 0.796 g of the title compound as a white solid: mp 222°-223° C. (softens 218° C.). MS (m/z) 340/342/344 (M+). HPLC indicates a major component (96.2%).

Provenance & Evidence