Hydrochloric Acid → HCID 54213334, compound

Participants

Reaction Steps

To a solution of methyl 5-bromo-5-chloroformylpentanoate (2.57 g) in diethyl ether (15 ml) was added a mixture of phenol (0.94 g) and diisopropylethylamine (1.30 g) in diethyl ether (10 ml). The mixture was stirred at room temperature for 15 minutes and poured into ice water and diluted hydrochloric acid. The organic layer was washed with water, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel eluting with a mixture of n-hexane and ethyl acetate (5:1) to give methyl 5-bromo-5-phenoxycarbonylpentanoate as an oil (2.33 g).

Provenance & Evidence