2-(2-Methoxycarbonyl-phenyl)-6-methyl-4-quinolinecarboxylic acid → HCID 15816898, compound

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Reaction Conditions

Reaction Steps

267 mg (0.831 mmol) of 2-(2-methoxycarbonylphenyl)-6-methyl-4-quinolinecarboxylic acid obtained in Example 4 was dissolved in 4.0 ml of diphenyl ether and heated at 225° C. for 10 minutes. After allowing the mixture to cool to room temperature, purification was carried out by flash silica gel chromatography using a mixed solvent of hexane and ethyl acetate (10/1) to obtain 154 mg of methyl 2-(6-methylquinolin-2-yl)benzoate. NMR (270 MHz, CDCl3):

Provenance & Evidence