反应详情

温度

60 °C

7.08 g (25.5 mmol) of methyl 2-(6-methylquinolin-2-yl)benzoate obtained in Example 5 was suspended in 75 ml of methanol and 35 ml of water in which 3.06 g (76.6 mmol) of sodium hydroxide was dissolved was added thereto. After heating at 60° C. for 3 hours, the reaction mixture was concentrated under reduced pressure and 200 ml of water was added to the residue. The resulting solution was acidified with 2N hydrochloric acid and the thus formed precipitate was collected by filtration. The precipitate was washed with water and dried to obtain 2-(6-methylquinolin-2-yl)benzoic acid. NMR (270 MHz, CD3OD):

1. additionwas added
2. concentrationthe reaction mixture was concentrated under reduced pressure and 200 ml of water
3. additionwas added to the residue
4. filtrationthe thus formed precipitate was collected by filtration
5. washThe precipitate was washed with water
6. customdried