Water → HCID 22370538, compound

Participants

Reaction Conditions

Reaction Steps

In 5 ml of quinoline was dissolved 0.1 g of the 2-(2-carboxyphenyl)-8-methyl-4-quinolinecarboxylic acid obtained in Example 11 and the solution was heated at 170° C. for 1.5 hours. Then the reaction mixture was poured into water, made alkaline by adding sodium hydroxide and washed with toluene. The aqueous layer was neutralized with 3M hydrochloric acid until a precipitate was formed. After extracting with dichloromethane, 0.05 g of 2-(8-methylquinolin-2-yl)benzoic acid were obtained. NMR (270 MHz, CD3OD): δ 7.5-8.3 (m,9H); 2.63 (s,3H).

Provenance & Evidence