Propylenediamine → 5-Oxo-pyrrolidine-3-carboxylic acid methyl ester

HRID 1956775Notes

Reaction equation

HRID 1956775 reaction equation
C(N)C([NH2:4])C.[C:6]([O:15][CH3:16])(=[O:14])[C:7]([CH2:9][C:10](OC)=[O:11])=[CH2:8]>>[C:6]([CH:7]1[CH2:8][NH:4][C:10](=[O:11])[CH2:9]1)([O:15][CH3:16])=[O:14]

Participants

3

Reactant 2

HCID 6567PropylenediamineHCID 69240Dimethyl itaconate

Product 1

HCID 131181175-Oxo-pyrrolidine-3-carboxylic acid methyl ester

Conditions

Temperature
140 °C

Procedure

Equimolar amounts of N-allyl, N-methyl, propylene diamine prepared as described above and Dimethyl Itaconate are charged to a reaction vessel and heated slowly with agitation to 130°-150° C. After the exotherm subsides, the reaction mixture is maintained at 140° C. for 3 hours. The reaction product 1-(N-allyl, N-methyl aminopropyl)-4-carbomethoxy pyrrolidone is isolated by distillation.

Workup

  1. additionare charged to a reaction vessel
  2. temperatureheated slowly with agitation to 130°-150° C

Sources & evidence

ORD record
ord-2f128ded16fc4eeca5c4eb08c431337a
Source dataset
uspto-grants-1998_07
Patent number
US05780639

Reaction notes

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