HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1956795Generated: November 1, 2026
Water → 2-(1-Benzylpyrrolidin-3-yl)acetonitrile
https://huagongshe.com/reaction/1956795
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-Benzyl-3-(chloromethyl)pyrrolidine | HCID 12364518 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(1-Benzylpyrrolidin-3-yl)acetonitrile | HCID 12364519 | 92% |
Reaction Steps
16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05780631 |
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| Source dataset | uspto-grants-1998_07 |
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| ORD ID | ord-a4befd5398cf480db9cca69b6f74a809 |
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| Source note | uspto-grants-1998_07 |
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