Pyridinium chloride → Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]phenyl-

Participants

Reaction Steps

2.5 g (6.7 mmol) of [2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][phenyl] methanone mixed with 10 g of pyridine hydrochloride and fused at 220° C. for 1.5 hours. The reaction mixture was poured into ice-water and mixture extracted with 500 mL of EtOAc. The EtOAc layer was separated, washed with brine, dried with MgSO4, and evaporated to a yellow oil. The product was crystallized from MeOH--HOH. This yielded 2.1 g of the title compound as yellow crystalline solid.

Provenance & Evidence