Butyl isocyanate → HCID 18349746, compound

HRID 1956844Notes

Reaction equation

HRID 1956844 reaction equation
[CH2:1]([N:5]=[C:6]=[O:7])[CH2:2][CH2:3][CH3:4].[NH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([NH:20][CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)([CH3:19])[CH3:18])=[CH:13][CH:12]=1>ClCCl>[CH2:1]([NH:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([NH:20][CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)([CH3:19])[CH3:18])=[CH:13][CH:12]=1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 8110Butyl isocyanateHCID 18349546HCID 18349546, compound

Product 1

HCID 18349746HCID 18349746, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of butylisocyanate (0.17 g) in dichloromethane was added to a solution of N-{1-[4-(2-aminoethyl)phenyl]-1-methylethyl}-3-(imidazol-1-yl)propylamine (0.5 g) in dichloromethane (7 ml). The mixture was boiled under reflux for 30 minutes and then the solvent removed under reduced pressure. The residue was purified by flash chromatography on silica using methanol as the mobile phase to give N-butyl-N'-[2-(4-{1-[3-(imidazol-1-yl)propylamino]-1-methylethyl}phenyl)ethyl]urea as an oil.

Workup

  1. temperatureunder reflux for 30 minutes
  2. customthe solvent removed under reduced pressure
  3. customThe residue was purified by flash chromatography on silica

Sources & evidence

ORD record
ord-387d61257d8e4ffd9daaaf9f3aad3721
Source dataset
uspto-grants-1998_07
Patent number
US05780642

Reaction notes

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