HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1956878Generated: October 26, 2026
Phenol → N-(1,1-dimethyl-2-phenoxyethyl)acetamide
https://huagongshe.com/reaction/1956878
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 4,5-Dihydro-2,4,4-trimethyloxazole | HCID 74496 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(1,1-dimethyl-2-phenoxyethyl)acetamide | HCID 18349669 | — |
Reaction Steps
A mixture of phenol (33.2 g) and 2,4,4-trimethyloxazoline (18.1 g) was heated in a stirred pressure vessel at 220° C. for 48 hours. The oil obtained on cooling was dissolved in ethyl acetate, washed with 5M sodium hydroxide solution, water, brine, then dried and evaporated to give an oil which was distilled under high vacuum to give N-(1,1-dimethyl-2-phenoxyethyl)acetamide, b.p. 115°-122° C. at 0.67 mbar.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05780642 |
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| Source dataset | uspto-grants-1998_07 |
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| ORD ID | ord-591ebd4134d24135a4e2325cd9418b18 |
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| Source note | uspto-grants-1998_07 |
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