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2-Amino-2-methyl-1-propanol → 2-[3-(Imidazol-1-yl)propylamino]-2-methyl-1-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| 反応物 | 1-(3,3-diethoxypropyl)-1H-imidazole | HCID 18349664 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-[3-(Imidazol-1-yl)propylamino]-2-methyl-1-propanol | HCID 18349765 | — |
反応手順
3-(Imidazol-1-yl)propionaldehyde diethyl acetal (8.1 g) was converted into the free aldehyde, as described in Example 24, and then added to a mixture of 2-amino-2-methylpropanol (1.83 g) in acetonitrile (40 ml) and 4A molecular sieves (6.0 g). The mixture was reacted following the procedure of Example 24 to give 2-[3-(imidazol-1-yl)propylamino]-2-methyl-1-propanol, m.p. 81°-85° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05780642 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-adc8701805e745bea74e019648928c15 |
| 出典メモ | uspto-grants-1998_07 |