HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride → 5-[4-(2-{1-[4-(4-Pyridylsulfonyl)phenyl]ethylideneaminooxy}ethoxy)benzyl]thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride | HCID 21833965 | — |
| Reactant | 1-[4-(Pyridine-4-sulfonyl)phenyl]ethan-1-one | HCID 21833995 | — |
| Product | 5-[4-(2-{1-[4-(4-Pyridylsulfonyl)phenyl]ethylideneaminooxy}ethoxy)benzyl]thiazolidine-2,4-dione | HCID 86751823 | 57.3% |
Reaction Steps
Following a procedure similar to that described in Example 40(f), but using 150 mg of 4'-(4-pyridylsulfonyl)acetophenone and 183 mg of 5-[4-(2-aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride [prepared as described in Example 40(e)], 173 mg of the title compound, melting at 213°-215° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780490 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-415c3d320aa744938200011b7e2aeba6 |
| Source note | uspto-grants-1998_07 |