HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride → 5-(4-{2-[1-(2',4'-Dimethoxybiphenyl-4-yl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride | HCID 21833965 | — |
| Reactant | 1-(2',4'-Dimethoxy-[1,1'-biphenyl]-4-yl)ethanone | HCID 21834044 | — |
| Product | 5-(4-{2-[1-(2',4'-Dimethoxybiphenyl-4-yl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione | HCID 86751825 | 89.8% |
Reaction Steps
Following a procedure similar to that described in Example 40(f), but using 256 mg of 4'-(2,4-dimethoxyphenyl)acetophenone and 382 mg of 5-[4-(2-aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride [prepared as described in Example 40(e)], 467 mg of the title compound, melting at 186°-188° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780490 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-e0cbc00f24274866b961ab79afd3ccd3 |
| Source note | uspto-grants-1998_07 |