HCID 9859505, compound → HCID 136395968, compound

HRID 1956945Notes

Reaction equation

HRID 1956945 reaction equation
[C:1]([O:4][C:5]1[C:6]([CH3:17])=[C:7]([CH3:16])[C:8]([OH:15])=[C:9]([C:12](=O)[CH3:13])[C:10]=1[CH3:11])(=[O:3])[CH3:2].Cl.[NH2:19][O:20][CH2:21][CH2:22][O:23][C:24]1[CH:37]=[CH:36][C:27]([CH2:28][CH:29]2[S:33][C:32](=[O:34])[NH:31][C:30]2=[O:35])=[CH:26][CH:25]=1>>[C:1]([O:4][C:5]1[C:6]([CH3:17])=[C:7]([CH3:16])[C:8]([OH:15])=[C:9]([C:12](=[N:19][O:20][CH2:21][CH2:22][O:23][C:24]2[CH:25]=[CH:26][C:27]([CH2:28][CH:29]3[S:33][C:32](=[O:34])[NH:31][C:30]3=[O:35])=[CH:36][CH:37]=2)[CH3:13])[C:10]=1[CH3:11])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 9859505HCID 9859505, compoundHCID 218339655-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride

Product 1

HCID 136395968HCID 136395968, compoundYield 44.6%

Procedure

Following a procedure similar to that described in Example 46, but using 0.32 g of 5'-acetoxy-2'-hydroxy-3',4',6'-trimethylacetophenone and 0.40 g of 5-[4-(2-aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride [prepared as described in Example 40(e)], 0.28 g of the title compound was obtained as an amorphous powder, melting at 60°-75° C. (softening point).

Sources & evidence

ORD record
ord-d5a87cc9d8c74ec8b9d49cf5f3f9fac1
Source dataset
uspto-grants-1998_07
Patent number
US05780490

Reaction notes

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