HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Hydroxy-3',5'-dimethylacetophenone → 5-(4-{2-[1-(4-Hydroxy-3,5-dimethylphenyl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Hydroxy-3',5'-dimethylacetophenone | HCID 36581 | — |
| Reactant | 5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride | HCID 21833965 | — |
| Product | 5-(4-{2-[1-(4-Hydroxy-3,5-dimethylphenyl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione | HCID 136395969 | 55.8% |
Reaction Steps
Following a procedure similar to that described in Example 46, but using 0.22 g of 4'-hydroxy-3',5'-dimethylacetophenone and 0.40 g of 5-[4-(2-aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride [prepared as described in Example 40(e)], 0.30 g of the title compound was obtained as an amorphous powder, melting at 53°-65° C. (softening point).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780490 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-a97948f938f9431785f91d4c507838aa |
| Source note | uspto-grants-1998_07 |