反应详情

To N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-pyrimidinyl)[1,1'-biphenyl]-2-sulfonamide (460 mg, 0.88 mmol, prepared as described in Step C of Example 16) in 10 ml MeOH, NaBH4 (40 mg, 1.06 mmol) was added. The reaction mixture was stirred at room temperature for 1.5 hrs and concentrated. To the residue, 10 ml H2O and 50 ml EtOAc were added. The organic layer was separated, washed with H2O, brine, dried and concentrated to give N-(4,5-dimethyl-3-isoxazolyl)-2'-(hydroxymethyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-pyrimidinyl)[1,1'-biphenyl]-2-sulfonamide.

1. concentrationconcentrated
2. additionTo the residue, 10 ml H2O and 50 ml EtOAc were added
3. customThe organic layer was separated
4. washwashed with H2O, brine
5. customdried
6. concentrationconcentrated