HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dimethylbenzoyl Chloride → HCID 67674610, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dimethylbenzoyl Chloride | HCID 81088 | — |
| Reactant | (R)-Methyl 2-amino-3-phenylpropanoate | HCID 853474 | — |
| Reactant | Methyl tryptophanate hydrochloride | HCID 2734891 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 67674858 | HCID 67674858 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 67674610 | HCID 67674610 | — |
Reaction Steps
Following the procedure described in example 12 and starting from N-(3,5-dimethylbenzoyl)-N-(1-methylpropyl)-(D)-phenylalanine (prepared by reductive alkylation of (D)-phenylalanine methyl ester with ethylmethylketone in the presence of sodium cyanoborohydride followed by N-acylation with 3,5-dimethylbenzoyl chloride in the presence of DMAP and hydrolysis of the methyl ester moiety according to example 1 and (L)-tryptophan methyl ester hydrochloride gives N-(3,5-dimethylbenzoyl)-N-(1-methylpropyl)-(D)-phenylalanyl-(L)-tryptophan; FAB-MS m/e 540 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780498 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-aaa0873cb9c247ae9d3a23fd5d2daa2c |
| Source note | uspto-grants-1998_07 |