Acetic Acid → HCID 67675855, compound

HRID 1956976Notes

Reaction equation

Cl.C[O:3][C:4](=[O:29])[C@H:5]([CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)[NH:6][C:7](=[O:18])[C@@H:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH:9][CH3:10].[C:30](O)(=[O:32])[CH3:31]>>[C:30]([N:9]([CH3:10])[C@@H:8]([C:7]([NH:6][C@H:5]([C:4]([OH:3])=[O:29])[CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)=[O:18])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)(=[O:32])[CH3:31]

Participants

Reactant 2

HCID 176Acetic Acid

HCID 67674832HCID 67674832, compound

Product 1

HCID 67675855HCID 67675855, compound

Procedure

Coupling of N-methyl-(D)-phenylalanyl-(L)-tryptophan methyl ester hydrochloride (see example 1) with acetic acid according to example 12 followed by hydrolysis of the methyl ester moiety according to example 1 gives N-acetyl-N-methyl-(D)-phenylalanyl-(L)-tryptophan; FAB-MS m/e 408 (M+H)+.

Sources & evidence

ORD record: ord-2609093021684da19dc43bda51a415b2
Source dataset: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05780498

Reaction notes

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