3,5-Difluorobenzoic acid → HCID 67674852, compound

HRID 1956983Notes

Reaction equation

HRID 1956983 reaction equation
Cl.C[O:3][C:4](=[O:29])[C@H:5]([CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)[NH:6][C:7](=[O:18])[C@@H:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH:9][CH3:10].[F:30][C:31]1[CH:32]=[C:33]([CH:37]=[C:38]([F:40])[CH:39]=1)[C:34](O)=[O:35]>>[F:30][C:31]1[CH:32]=[C:33]([CH:37]=[C:38]([F:40])[CH:39]=1)[C:34]([N:9]([CH3:10])[C@@H:8]([C:7]([NH:6][C@H:5]([C:4]([OH:3])=[O:29])[CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)=[O:18])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:35]

Participants

3

Reactant 2

HCID 1012653,5-Difluorobenzoic acidHCID 67674832HCID 67674832, compound

Product 1

HCID 67674852HCID 67674852, compound

Procedure

Coupling of N-methyl-(D)-phenylalanyl-(L)-tryptophan methyl ester hydrochloride (see example 1) with 3,5-difluorobenzoic acid according to example 12 followed by hydrolysis of the methyl ester moiety according to example 1 gives N-(3,5-difluorobenzoyl)-N-methyl-(D)-phenylalanyl-(L)-tryptophan; FAB-MS m/e 506 (M+H)+.

Sources & evidence

ORD record
ord-d461f3ec06d842dfa671c5af87132d20
Source dataset
uspto-grants-1998_07
Patent number
US05780498

Reaction notes

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