3-Methyl-1-Cyclohexanecarboxylic Acid → HCID 86752915, compound

HRID 1956985Notes

Reaction equation

HRID 1956985 reaction equation
Cl.C[O:3][C:4](=[O:29])[C@H:5]([CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)[NH:6][C:7](=[O:18])[C@@H:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH:9][CH3:10].[CH3:30][CH:31]1[CH2:36][CH2:35][CH2:34][CH:33]([C:37](O)=[O:38])[CH2:32]1>>[CH3:30][CH:31]1[CH2:36][CH2:35][CH2:34][CH:33]([C:37]([N:9]([CH3:10])[C@@H:8]([C:7]([NH:6][C@H:5]([C:4]([OH:3])=[O:29])[CH2:19][C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH:21]=2)=[O:18])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:38])[CH2:32]1

Participants

3

Reactant 2

HCID 1144903-Methyl-1-Cyclohexanecarboxylic AcidHCID 67674832HCID 67674832, compound

Product 1

HCID 86752915HCID 86752915, compound

Procedure

Coupling of N-methyl-(D)-phenylalanyl-(L)-tryptophan methyl ester hydrochloride (see example 1) with 3-methyl-1-cyclohexanecarboxylic acid according to example 12 followed by hydrolysis of the methyl ester moiety according to example 1 gives N-(3-methyl-1-cyclohexylcarbonyl)-N-methyl-(D)-phenylalanyl-(L)-tryptophan; FAB-MS m/e 490 (M+H)+.

Sources & evidence

ORD record
ord-a2a337917f0f4f1998ae748781b190cb
Source dataset
uspto-grants-1998_07
Patent number
US05780498

Reaction notes

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