2-Methylbutanoic Acid → HCID 67675738, compound

HRID 1956987Notes

Reaction equation

HRID 1956987 reaction equation
Cl.C[O:3][C:4](=[O:29])[C@H:5]([CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)[NH:6][C:7](=[O:18])[C@@H:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH:9][CH3:10].[CH3:30][CH:31]([CH2:35][CH3:36])[C:32](O)=[O:33]>>[CH3:30][CH:31]([CH2:35][CH3:36])[C:32]([N:9]([CH3:10])[C@@H:8]([C:7]([NH:6][C@H:5]([C:4]([OH:3])=[O:29])[CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)=[O:18])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:33]

Participants

3

Reactant 2

HCID 83142-Methylbutanoic AcidHCID 67674832HCID 67674832, compound

Product 1

HCID 67675738HCID 67675738, compound

Procedure

Coupling of N-methyl-(D)-phenylalanyl-(L)-tryptophan methyl ester hydrochloride (see example 1) with 2-methylbutyric acid according to example 12 followed by hydrolysis of the methyl ester moiety according to example 1 gives N-(2-methylbutyroyl)-N-methyl-(D)-phenylalanyl-(L)-tryptophan; FAB-MS m/e 450 (M+H)+.

Sources & evidence

ORD record
ord-fbb76b7eded44755a3f48d22d62a61dd
Source dataset
uspto-grants-1998_07
Patent number
US05780498

Reaction notes

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