(1,1'-Biphenyl)-4-carboxylic acid → HCID 67675255, compound

HRID 1956993Notes

Reaction equation

HRID 1956993 reaction equation
Cl.C[O:3][C:4](=[O:29])[C@H:5]([CH2:19][C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH:21]=1)[NH:6][C:7](=[O:18])[C@@H:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH:9][CH3:10].[C:30]1([C:36]2[CH:44]=[CH:43][C:39]([C:40](O)=[O:41])=[CH:38][CH:37]=2)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[C:30]1([C:36]2[CH:37]=[CH:38][C:39]([C:40]([N:9]([CH3:10])[C@@H:8]([C:7]([NH:6][C@H:5]([C:4]([OH:3])=[O:29])[CH2:19][C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[NH:22][CH:21]=3)=[O:18])[CH2:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[O:41])=[CH:43][CH:44]=2)[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 67674832HCID 67674832, compound

Product 1

HCID 67675255HCID 67675255, compound

Procedure

Coupling of N-methyl-(D)-phenylalanyl-(L)-tryptophan methyl ester hydrochloride (see example 1) with 4-phenylbenzoic acid according to example 12 followed by hydrolysis of the methyl ester moiety according to example 1 gives N-(4-phenylbenzoyl)-N-methyl-(D)-phenylalanyl-(L)-tryptophan; FAB-MS m/e 546 (M+H)+.

Sources & evidence

ORD record
ord-9b1a278c69bb4330b6bced74dfeaa363
Source dataset
uspto-grants-1998_07
Patent number
US05780498

Reaction notes

Loading…