HRID1957004

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID71098

D-Tyrosine

C9H11NO3

HCID2734891

Methyl tryptophanate hydrochloride

C12H15ClN2O2

结构：Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(O)cc2)C(=O)O)c1

HCID67676289

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1

HCID67675232

未命名化合物

PROCEDURE

实验过程

Coupling of N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosine (prepared from (D)-tyrosine following the procedure described in example 55) with (L)-tryptophan methyl ester hydrochloride according to example 1 followed by hydrolysis of the methyl ester moiety according to example 12 gives N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosyl-(L)-tryptophan; FAB-MS m/e 512 (M-H)-.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a2e3e0819ec84fec9c06fce8526bf83a
来源数据集: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05780498
来源说明: uspto-grants-1998_07

反应 SMILES

[CH3:1][C:2]1[CH:3]=[C:4]([CH:21]=[C:22]([CH3:24])[CH:23]=1)[C:5]([N:7]([CH3:20])[C@@H:8]([C:17](O)=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)=[O:6].N[C@@H](C(O)=O)CC1C=CC(O)=CC=1.Cl.C[O:40][C:41](=[O:54])[C@H:42]([CH2:44][C:45]1[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[NH:47][CH:46]=1)[NH2:43]>>[CH3:24][C:22]1[CH:21]=[C:4]([CH:3]=[C:2]([CH3:1])[CH:23]=1)[C:5]([N:7]([CH3:20])[C@@H:8]([C:17]([NH:43][C@H:42]([C:41]([OH:40])=[O:54])[CH2:44][C:45]1[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[NH:47][CH:46]=1)=[O:18])[CH2:9][C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=1)=[O:6]