HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl tryptophanate hydrochloride → N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosyl-(L)-tryptophan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl tryptophanate hydrochloride | HCID 2734891 | — |
| Reactant | N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosyl-(L)-tryptophan | HCID 67675232 | — |
| Product | N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosyl-(L)-tryptophan | HCID 67674609 | — |
Reaction Steps
Coupling of N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosine (prepared by O-benzylation of N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosine (example 64)) with (L)-tryptophan methyl ester hydrochloride according to example 1 followed by hydrolysis of the methyl ester moiety according to example 12 gives N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosyl-(L)-tryptophan; FAB-MS m/e 602 (M-H)-.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780498 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-d5c8e86e343a4f9e9a86ba8ac1dd295f |
| Source note | uspto-grants-1998_07 |