HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 86752918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 67675222 | HCID 67675222 | — |
| Reactant | Methyl (2S)-2-amino-4-phenylbutanoate--hydrogen chloride (1/1) | HCID 69121669 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 86752918 | HCID 86752918 | — |
Reaction Steps
Coupling of N-(3,5-dimethylbenzoyl)-N-methyl-(D)-phenylalanine (derived from the corresponding methylester described in example 78 by hydrolysis with lithium hydroxide in methanol/water: [a]D =+88° (c=1.0, ethanol)) with (L)-homo-phenylalanine methyl ester hydrochloride according to example 1 followed by hydrolysis of the methyl ester moiety according to example 12 gives N-(3,5-dimethylbenzoyl)-N-methyl-(D)-phenylalanyl-(L)-homo-phenylalanine; FAB-MS m/e 473 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780498 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-c0721605975d4acfb5623a7c80dac504 |
| Source note | uspto-grants-1998_07 |