反应详情

5-(4-bromomethylphenyl)-isoxazole (700 mg) and N-diphenylmethylene-glycine ethyl ester (890 mg) are dissolved in dichloromethane (20 ml) and stirred vigorously with a solution of tetrabutylammonium hydrogensulfate in 2.5 molar aqueous sodium hydroxide, at room temperature, over night. The organic layer is then separated off and concentrated. The residue is partitioned between ether and water, the etherphase washed with water and brine, dried over magnesium sulfate and evaporated to give crude N-diphenylmethylene-3-[4-(5-isoxazolyl)-phenyl]-alanine ethyl ester, which is used for the next step without further purification.

1. customThe organic layer is then separated off
2. concentrationconcentrated
3. customThe residue is partitioned between ether and water
4. washthe etherphase washed with water and brine
5. dry with materialdried over magnesium sulfate
6. customevaporated