HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 4-Acetyl-4-phenylpiperidine hydrobromide | HCID 21200462 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide | HCID 22741756 | 93.4% |
Reaction Steps
7.9 g of bromine are added rapidly at RT to a suspension of 14 g of 4-acetyl-4-phenylpiperidine hydrobromide in 200 ml of DCM and the reaction mixture is stirred overnight at RT. It is diluted by the addition of 200 ml of ether and the precipitate formed is wrung and washed with ether to give 16.7 g of the expected product after drying under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780466 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-3f3b3eaf5f694adf97c68d63b975d200 |
| Source note | uspto-grants-1998_07 |