Acetic Anhydride → HCID 19068585, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 ml round bottom flask with stirbar, reflux condenser and nitrogen bubbler was placed the 4-(4-oxo-4Hpyridin-1-yl)hexylbenzene (0.638 g, 2.5 mmol), octylcyanoacetate (1.97 g, 10 mmol) and acetic anhydride (5.0 g). This mixture was heated in a 140° C. oil bath for 4.0 hours. After this period the mixture was cooled and crystalline product was isolated by suction filtration and washed well with acetic anhydride. The crude product was crystallized once from 1-propanol as yellow crystals (0.90 g, 83%).

Provenance & Evidence