Sodium Hydroxide → HCID 86751975, compound

HRID 1957106Notes

Reaction equation

HRID 1957106 reaction equation
[C:1]([NH:4][C@H:5]1[C@H:16]([C@@H:17]([C@@H:19]([CH2:21][OH:22])[OH:20])[OH:18])[O:15][C@:8]([O:13][CH3:14])([C:9]([O:11]C)=[O:10])[CH2:7][C@@H:6]1[OH:23])(=[O:3])[CH3:2].[OH-].[Na+:25]>>[C:1]([NH:4][C@H:5]1[C@H:16]([C@@H:17]([C@@H:19]([CH2:21][OH:22])[OH:20])[OH:18])[O:15][C@:8]([O:13][CH3:14])([C:9]([O-:11])=[O:10])[CH2:7][C@@H:6]1[OH:23])(=[O:3])[CH3:2].[Na+:25]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 10893079HCID 10893079, compound

Product 1

HCID 86751975HCID 86751975, compound

Procedure

To methyl 5-acetamido-3,5-dideoxy-2-O-methyl-β-D-glycero-D-galacto-2-nonulopyranosonate (3.06 g, 9.07 mmol) was added 0.1N aqueous solution of sodium hydroxide (100 ml, 10.0 mmol) under ice cooling and then the mixture was stirred at room temperature for 22 hours. The reaction mixture was neutralized by addition of Dowex (50 W×8, H+) resin. The resin was filtered off and the filtrate was concentrated to obtain sodium 5-acetamido-3,5-dideoxy-2-O-methyl-β-D-glycero-D-galacto-2-nonulopyranosonate as an oil.

Workup

  1. additionThe reaction mixture was neutralized by addition of Dowex (50 W×8, H+) resin
  2. filtrationThe resin was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-eece98c9efbf40a19bb7f11910a94f9b
Source dataset
uspto-grants-1998_07
Patent number
US05783564

Reaction notes

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