1H-1,2,4-Triazole → HCID 10617092, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromomethyl-6,7-dichloro-2,3-diethoxyquinoxaline (Preparation 1,176 mg, 0.5 mmol), 1,2,4-triazole (69 mg, 1.0 mmol) and anhydrous potassium carbonate (138 mg, 1.0 mmol) in dry N,N-dimethylacetamide (2 mL) was heated at 50° C. with stirring for 18 hours. The mixture was diluted with ethyl acetate, washed with water, and concentrated under reduced pressure. The residue was purified by flash chromatography using a hexane:ethyl acetate:methanol gradient to give 6,7-dichloro-2,3-dimethoxy-5-(1,2,4-triazol-1-ylmethyl)quinoxaline (99 mg, 58%).

Provenance & Evidence