Ammonium Chloride → HCID 10499233, compound

Participants

Reaction Steps

A solution of diisobutylaluminium hydride (1M in dichloromethane, 9 mL, 9 mmol) was added dropwise to a stirred suspension of 6,7-dichloro-2,3-dimethoxy-5-[(4-methoxycarbonyl-1,2,3-triazol-1-yl)methyl]quinoxaline (1.087 g, 2.73 mmol) under nitrogen at -78° C. After 2.25 hours, methanol (5 mL) was added, followed by saturated aqueous ammonium chloride (25 mL) 5 minutes later. The mixture was allowed to warm to room temperature, filtered through Arbocel filter aid, washing the filter cake with dichloromethane. The organic solution was dried (MgSO4) and concentrated under reduced pressure to give 6,7-dichloro-2,3-dimethoxy-5[(4-formyl-1,2,3-triazol-1-yl)methyl]quinoxaline (981 mg, 98%), as a white solid.

Provenance & Evidence