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Hydride → 2-(1-Benzhydrylazetidin-3-YL)ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydride | HCID 166653 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | 3-Cyanomethyl-1-benzhydryl azetidine | HCID 22257633 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(1-Benzhydrylazetidin-3-YL)ethanamine | HCID 22257634 | 87% |
反応手順
5.7 g (21.7 mmol) of 3-cyanomethyl-l-benzhydryl azetidine was added slowly to a suspention of 2.9 g (76.0 mmol) of LiAlH4 in 80 mL of dry THF at roomtemperature. The reaction mixture was refluxed for 4 h. Excess hydride reagent was hydrolyzed by careful addition, with cooling, of NH4 Cl(aq), the gelatinous mixture was filtered and the filter cake was washed repeatedly with THF. The solvent was evaporated, the residue was dissolved in diethyl ether, washed with brine and dried with Na2SO4. Evaporation of the solvent gave 5.0 g (87%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05783563 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-aa7105c9403940bc892562f70c7c4301 |
| 出典メモ | uspto-grants-1998_07 |