Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl 4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Phenol, 3-(1,1-dimethylethyl)- | HCID 11450 | — |
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | Methyl 4-chloro-6-dimethylamino-pyrimidin-5-yl-acetate | HCID 53722653 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate | HCID 19069025 | 87.4% |
반응 단계
A mixture of methyl 4-chloro-6-dimethylamino-pyrimidin-5-yl-acetate (22.9 g, 100 mmol), 3-tert.butylphenol (15.0 g, 100 mmol), potassium carbonate (20.7 g, 150 mmol) and a catalytic amount of 18-crown-6 is heated in dimethylformamide (50 ml) at +130° C. for 6 hours. The reaction mixture is diluted with diethyl ether, washed with 2 n NaOH and brine, dried (MgSO4) and evaporated to give methyl 4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate as a yellow oil (30 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05783580 |
| 출처 데이터셋 | uspto-grants-1998_07 |
| ORD ID | ord-7c76342a935f4434a12659179e5cdc15 |
| 출처 메모 | uspto-grants-1998_07 |