HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → Methyl alpha-[4-(3-bromomethylphenoxy)-6-methoxy-5-pyrimidinyl]-beta-methoxyacrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl alpha-[4-(3-methylphenoxy)-6-methoxy-pyrimidin-5-yl)-beta-methoxyacrylate | HCID 57241123 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Methyl alpha-[4-(3-bromomethylphenoxy)-6-methoxy-5-pyrimidinyl]-beta-methoxyacrylate | HCID 53821122 | — |
Reaction Steps
Methyl α-[4-(3-methylphenoxy)-6-methoxy-pyrimidin-5-yl]-β-methoxyacrylate (2.7, 8.4 mmol), N-bromosuccinimide (1.6 g, 6 mmol) and a catalytic amount of AIBN are refluxed in CCl4 for 90 minutes. Filtration of the succinimide and evaporation of the solvent gives the methyl α-[4-(3-bromomethylphenoxy)-6-methoxy-pyrimidin-5-yl]-β-methoxyacrylate as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05783580 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-c7db5a6ff94e452392dc8b03caefc779 |
| Source note | uspto-grants-1998_07 |