HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957175Generated: November 1, 2026
Dimethylamine → Methyl 4-(3-acetylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate
https://huagongshe.com/reaction/1957175
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-Hydroxyacetophenone | HCID 8487 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate | HCID 54165419 | — |
| Product | Methyl 4-(3-acetylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate | HCID 54226209 | — |
Reaction Steps
A mixture of methyl 4,6-dichloropyrimidin-5-yl-acetate (221 g, 1 mol), 3-hydroxyacetophenone (136 g, 1 mol) and K2CO3 (207 g, 1.5 mol) in DMF (150 mol) is stirred at 100° C. for 90 minutes. The dark mixture is cooled to 0° C. and dimethylamine (450 ml of a 40% aqeous solution) is added. Stirring is continued at room temperature for 16 hours. Dilution with water and extraction with ether gives methyl 4-(3-acetylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate as a brownish oil (purity>95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05783580 |
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| Source dataset | uspto-grants-1998_07 |
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| ORD ID | ord-ee4e0e0e4ce749b0a9a41ef757b692b5 |
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| Source note | uspto-grants-1998_07 |
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