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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957188Generated: November 1, 2026

Methyl iodide → 2-Chloro-1-methyl-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/1957188

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
ReactantSodium hydrideHCID 24758—
Reactant2-chloro-1H-indole-3-carbaldehydeHCID 314791—
Product2-Chloro-1-methyl-1H-indole-3-carbaldehydeHCID 31479293.8%

Reaction Steps

Prepared from (1) (18 g), methyl iodide (17.1 g) and NaH (2.88 g) yielding (3) (18.2 g), m.p. 88°-90° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05783575
Source datasetuspto-grants-1998_07
ORD IDord-9ce03d67c690419cb52c36d38440a9ef
Source noteuspto-grants-1998_07