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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957209Generated: November 1, 2026

Potassium Hydroxide → 4,6-Dichloro-8-methylthieno[2,3-b]indole-2-carboxylic acid

https://huagongshe.com/reaction/1957209

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
ReactantMethyl 4,6-dichloro-8-methylthieno[2,3-b]indole-2-carboxylateHCID 19068958—
Product4,6-Dichloro-8-methylthieno[2,3-b]indole-2-carboxylic acidHCID 1906894279.5%

Reaction Steps

Prepared from KOH (2.23 g), (53) (2.20 g) after reflux for 4 1/3 h yielding (56) 1.67 g (79.5%). M.p. 278°-281° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05783575
Source datasetuspto-grants-1998_07
ORD IDord-11ef2d2cce8e4e999a3df08584f11424
Source noteuspto-grants-1998_07