HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 19068966, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Morpholine, hydrochloride (1:1) | HCID 197884 | — |
| Reactant | HCID 19068968 | HCID 19068968 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19068966 | HCID 19068966 | — |
Reaction Steps
280 mg of (68) was added to 25 ml of THF, 0.5 ml of SOCl2 was added, and the reaction left with stirring for 1 hour. 1 ml of morpholine was added in portions, and stirring continued . The precipitated morpholine hydrochloride was filtrered off, and the solvent evaporated. The residue was purified by column chromatography on silica gel, using MeOH in CH2Cl2, 1+9 as the eluent. MeOH was added to the pooled fractions to precipitate the product, giving after filtration and drying 50 mg of (69). M.p. 250°-2° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05783575 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-4041411e34354ac59a5c90c7a9aeedd6 |
| Source note | uspto-grants-1998_07 |