Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-(Trifluoroacetoxy)pyridine | HCID 4638214 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | HCID 19068992 | HCID 19068992 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 19068959 | HCID 19068959 | — |
Reaction Steps
A mixture of 1 g of (73) and 1.1 g of 2-trifluoromethylcarbonyloxypyridine, prepared according to the literature (Keumi, T. et. al. Chem. Lett. 5 (1990) 783-6), in 25 ml of 1,2-dichloroethane, was cooled to -10° C. with stirring. 1.5 g of AlCl3 was added over 15 minutes at this temperature, the reaction mixture was stirred at 0° C. for 4 hours, and at room temperature overnight. Water was added, the phases separated, and the organic phase dried and evaporated to dryness. Purification by column chromatography on silica gel in toluene gave the pure (74). Yield 590 mg. M.p. 138°-40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05783575 |
|---|
| Source dataset | uspto-grants-1998_07 |
|---|
| ORD ID | ord-8ab7dda9d82e4969aba388d162b03ace |
|---|
| Source note | uspto-grants-1998_07 |
|---|
