HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(1-Methyl-2-chloro-3-indolyl)-2-methylsulfonylacrylonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (Methylsulfonyl)acetonitrile | HCID 75283 | — |
| Reactant | 2-Chloro-1-methyl-1H-indole-3-carbaldehyde | HCID 314792 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(1-Methyl-2-chloro-3-indolyl)-2-methylsulfonylacrylonitrile | HCID 53939750 | — |
Reaction Steps
To 550 mg of 1-methyl-2-chloroindole-3-carbaldehyde, dissolved in 25 ml of THF, was added 730 mg of methylsulfonylacetonitril and 1.2 g of triethylamine. After 24 hours another 300 mg of methylsulfonylacetonitril was added, and the mixture was stirred for 6 days. The precipitate was collected by filtration to give (3a). Yield 630 mg of (3a), m.p. 180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05783575 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-9eb0e228c0f0488a9229d57f92509cc7 |
| Source note | uspto-grants-1998_07 |