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2,3-Dichloro-5-(trifluoromethyl)pyridine → 2-(4-Chloro-2-fluoro-5-methoxyphenyl)-3-chloro-5-trifluoromethylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Dichloro-5-(trifluoromethyl)pyridine | HCID 112234 | — |
| 反応物 | (4-Chloro-2-fluoro-5-methoxyphenyl)boronic acid | HCID 10932600 | — |
| 反応物 | 3-Chloro-2-(4-chloro-3-methoxyphenyl)-5-trifluoromethylpyridine | HCID 15766876 | — |
| 生成物 | 2-(4-Chloro-2-fluoro-5-methoxyphenyl)-3-chloro-5-trifluoromethylpyridine | HCID 11002295 | 19% |
反応手順
In a preparation similar to that described above for 3-chloro-2-(4-chloro-3-methoxyphenyl)-5-trifluoromethylpyridine, reaction of 8.9 g (41 mmol) of 2,3-dichloro-5-trifluoromethylpyridine and 7.9 g (41 mmol) of 4-chloro-2-fluoro-5-methoxybenzeneboronic acid and subsequent purification of the crude product by chromatography on silica gel (methylene chloride as eluent) resulted in 2.6 g of colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05783522 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-d60befcae584477ba75be131f7f71d7c |
| 出典メモ | uspto-grants-1998_07 |