Sodium Methoxide → HCID 15766881, compound

Participants

Reaction Steps

A solution of 3.6 g (7.78 mmol) of 3-chloro-2-[4-chloro-3-bis-(methylsulfonyl)aminophenyl]-5-trifluoromethylpyridine (prepared as in Example 13) and 100 mg of sodium methoxide in 100 ml of methanol were stirred at 20°-25° C. for three hours. Then most of the methanol was distilled off under reduced pressure. The residue was taken up in dilute hydrochloric acid, after which the product was extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated. The oily residue was treated with ether/petroleum ether to afford 1.6 g (53%) of colorless crystals of melting point 133°-134° C.

Provenance & Evidence