Sulfuric Acid → 2-Chloro-5-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]benzaldehyde

Participants

Reaction Steps

6.99 g (15.1 mmol) of 3-chloro-2-(4-chloro-3-dibromomethylphenyl)-5-trifluoromethylpyridine in 100 ml of 96% strength sulfuric acid were stirred at 100° C. for one hour during which a vigorous stream of nitrogen was passed through the reaction mixture. The mixture was cooled and then poured into ice-water. The solid product was separated off, washed with water and dried under reduced pressure. Yield: 4.2 g (87%) of colorless crystals of melting point 94° C.

Provenance & Evidence