Thionyl Chloride → 3-Chloro-2-(4-chloro-3-chloroformylphenyl)-5-trifluoromethylpyridine

HRID 1957267Notes

Reaction equation

HRID 1957267 reaction equation
[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([C:19](O)=[O:20])[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.S(Cl)([Cl:24])=O>>[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([C:19]([Cl:24])=[O:20])[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:9])([F:11])[F:10])[CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 19068766HCID 19068766, compound

Product 1

HCID 190687513-Chloro-2-(4-chloro-3-chloroformylphenyl)-5-trifluoromethylpyridine

Procedure

23 g of 3-chloro-2-(4-chloro-3-hydroxycarbonylphenyl)-5-trifluoromethylpyridine in 23 ml of thionyl chloride were refluxed for 5 hours. The excess thionyl chloride was then removed by distillation. The remaining dark brown oil was used without further purification for the subsequent reaction.

Workup

  1. customThe excess thionyl chloride was then removed by distillation
  2. customThe remaining dark brown oil was used without further purification for the subsequent reaction

Sources & evidence

ORD record
ord-cb41da4bdf4249e79700dfa075247121
Source dataset
uspto-grants-1998_07
Patent number
US05783522

Reaction notes

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