HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1957268Generated: November 2, 2026
Ammonia → 2-(3-Carbamoyl-4-chlorophenyl)-3-chloro-5-trifluoromethylpyridine
https://huagongshe.com/reaction/1957268
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Chloro-2-(4-chloro-3-chloroformylphenyl)-5-trifluoromethylpyridine | HCID 19068751 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3-Carbamoyl-4-chlorophenyl)-3-chloro-5-trifluoromethylpyridine | HCID 19068750 | — |
Reaction Steps
A solution of 4.0 g of 3-chloro-2-(4-chloro-3-chloroformylphenyl)-5-trifluoromethylpyridine in 10 ml of methylene chloride was added dropwise to 100 ml of a 25% by weight aqueous ammonia solution cooled to 0° C. After 3 hours, the crystals which had formed were separated off, stirred with n-hexane, again separated off, washed with n-hexane and finally dried. Yield: 2.8 g (75%) of colorless crystals; melting point: 167°-168° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05783522 |
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| Source dataset | uspto-grants-1998_07 |
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| ORD ID | ord-bc85ef746d7846e9aeba4adfda26db97 |
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| Source note | uspto-grants-1998_07 |
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